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Insulin is made when the blood sugar level is very high. Allows the liver to conserve glucose as glycogen.
Insulin is made the the Beta-cells of the pancreas.
Insulin binds to GLUT receptors which up-regulate or down-regulate the intake of glucose into the cells. References :
Your pancreas secretes insulin in response to fluctuating blood sugar levels. The glycolysis/carbohydrate metabolism pathways of individual cells sends signals through the blood stream to the brain, which is monitoring blood glucose levels. If the blood glucose levels drop, the brain signals the pancreas to release glucagon, which in turn affects the liver to start converting the stored glycogen to glucose. As the glucose level in the blood stream rises, the brain signals the pancreas to produce more insulin, in order to carry the glucose into the cells, this also affects the liver which increases glycogen stores. It's a negative feedback loop of glycolysis and glycogenesis. References : http://en.wikipedia.org/wiki/Blood_glucose_level
RN
Insulin is produced in the Islets of Langerhans in the pancreas. Beta cells in the islets of Langerhans are sensitive to variations in blood glucose levels.
The main mechanism for controlling its release are glucose blood levels. Levels normally remain within a narrow range. In most humans this varies from about 70 mg/dl to perhaps 110 mg/dl (3.9 to 6.1 mmol/litre) except shortly after eating when the blood glucose level rises temporarily. There are two types of mutually antagonistic(work against each other) metabolic hormones affecting blood glucose levels:
Catabolic hormones (such as glucagon, growth hormone, and catecholamines), which increase blood glucose
and one anabolic hormone (insulin), which decreases blood glucose. This means that these hormons act to counter each other so blood level remian in a certain range. So the conrol mechanism for insulin is the action of other hormones, such as glucagon, growth hormone, and catecholamines. Which are depedent on blood sugar levels, which insulin helps controll
This is a general answer, the whole metabolic control system involving insulin and it exact mechanisms could fill a text book. References :
So many people will say the hypothalamus will detect low BSL (blood sugal levels) and stimulate the release of insulin from the pancreas. That is wrong!!! The pancreas does it all by itself and causes the beta cells in the islets of langerhans to release insulin into the blood.
Such a big exam question!! Very common! References :
November 16th, 2008 at 4:38 pm
Insulin…?
What is the control mechanism for insulin?
November 16th, 2008 at 9:40 pm
Depends how in depth you want the answer:
Insulin is made when the blood sugar level is very high. Allows the liver to conserve glucose as glycogen.
Insulin is made the the Beta-cells of the pancreas.
Insulin binds to GLUT receptors which up-regulate or down-regulate the intake of glucose into the cells.
References :
November 16th, 2008 at 9:42 pm
Your pancreas secretes insulin in response to fluctuating blood sugar levels. The glycolysis/carbohydrate metabolism pathways of individual cells sends signals through the blood stream to the brain, which is monitoring blood glucose levels. If the blood glucose levels drop, the brain signals the pancreas to release glucagon, which in turn affects the liver to start converting the stored glycogen to glucose. As the glucose level in the blood stream rises, the brain signals the pancreas to produce more insulin, in order to carry the glucose into the cells, this also affects the liver which increases glycogen stores. It's a negative feedback loop of glycolysis and glycogenesis.
References :
http://en.wikipedia.org/wiki/Blood_glucose_level
RN
November 16th, 2008 at 9:44 pm
Insulin is produced in the Islets of Langerhans in the pancreas. Beta cells in the islets of Langerhans are sensitive to variations in blood glucose levels.
The main mechanism for controlling its release are glucose blood levels. Levels normally remain within a narrow range. In most humans this varies from about 70 mg/dl to perhaps 110 mg/dl (3.9 to 6.1 mmol/litre) except shortly after eating when the blood glucose level rises temporarily. There are two types of mutually antagonistic(work against each other) metabolic hormones affecting blood glucose levels:
Catabolic hormones (such as glucagon, growth hormone, and catecholamines), which increase blood glucose
and one anabolic hormone (insulin), which decreases blood glucose. This means that these hormons act to counter each other so blood level remian in a certain range. So the conrol mechanism for insulin is the action of other hormones, such as glucagon, growth hormone, and catecholamines. Which are depedent on blood sugar levels, which insulin helps controll
This is a general answer, the whole metabolic control system involving insulin and it exact mechanisms could fill a text book.
References :
November 16th, 2008 at 9:46 pm
PANCREAS
that is such a big test question!!
So many people will say the hypothalamus will detect low BSL (blood sugal levels) and stimulate the release of insulin from the pancreas. That is wrong!!! The pancreas does it all by itself and causes the beta cells in the islets of langerhans to release insulin into the blood.
Such a big exam question!! Very common!
References :